CTX-M β-Lactamases in Escherichia coli from Community-acquired Urinary Tract Infections, Cambodia

نویسندگان

  • Etienne Ruppé
  • Sopheak Hem
  • Sovannarith Lath
  • Valérie Gautier
  • Frédéric Ariey
  • Jean-Louis Sarthou
  • Didier Monchy
  • Guillaume Arlet
چکیده

Despite the recent global spread of CTX-M beta-lactamases in Escherichia coli isolates from community-acquired urinary tract infections (CA-UTIs), their dissemination has been little studied in developing countries. In a 2-year prospective study, we documented the prevalence of extended-spectrum beta-lactamases (ESBLs) in E. coli that were responsible for CA-UTIs in Phnom-Penh, Cambodia. Ninety-three E. coli strains were included. We observed a high prevalence of resistance to amoxicillin (88.2% of strains), cotrimoxazole (75.3%), ciprofloxacin (67.7%), gentamicin (42.5%), and third-generation cephalosporins (37.7%). A total of 34 strains carried ESBLs, all of which were CTX-M type. CTX-M carriage was associated with resistance to fluoroquinolones and aminoglycosides. U using repetitive extragenic palindromic-PCR, we identified 4 clusters containing 9, 8, 3, and 2 strains. The prevalence of CTX-M beta-lactamases has reached a critical level in Cambodia, which highlights the need for study of their spread in developing countries.

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عنوان ژورنال:
  • Emerging Infectious Diseases

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2009